All patches are rolled into the next version that we release, so all registered users get all the latest fixes whenever they upgrade to the latest version of Mezzmo. So, if you have the current version of Mezzmo (v3.4.4.0) then you have all the latest patches, fixes & device support. Any new patches that we create are just for people that cannot wait for the upcoming version or for people that are helping us test if the patches actually fix the problem.
Regarding your problem, make sure you are running the current version of Mezzmo (v3.4.4.0). Also, check that your device profile is set to 'Xbox 360' in the Media Devices dialog.
If still no success, then right-click on one of the MP4 files in Mezzmo that do not play on your Xbox and click 'Get FFmpeg Information'. Post that here or email it to us at support [at] conceiva [dot] com.
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